What is brain-derived neurotrophic factor (BDNF)?

What is brain-derived neurotrophic factor (BDNF)? [url=https://www.rxshopmd.com/products/antinarcoleptic/buy-modafinil-modalert/]modalert vs modafinil[/url] п»ї<title>What is brain-derived neurotrophic factor (BDNF)?</title> [IMG]https://lamenteesmaravillosa.com/wp-content/uploads/2020/09/cerebro-iluminado-activo-1024x683.jpg[/IMG] As our body develops, grows and matures, so does our brain. Contrary to the old belief that we were born with a certain number of neurons and no more could be created, in the 1980s they discovered a protein, "small, but tough", capable of stimulating the development of new neurons. It is brain-derived neurotrophic factor or BDNF. This protein is responsible for the development of cognitive capacity, memory, learning ability and other cognitive processes. But it also counteracts the effects of stress on the brain and acts as a natural antidepressant. A real gem. Want to know more about brain-derived neurotrophic factor? We will learn about its mechanism of action, its function in the nervous system, how certain diseases affect BDNF levels and what we can do to naturally increase the levels of this important protein. What is brain-derived neurotrophic factor or BDNF? brain-derived neurotrophic factor, also known as BDNF, is a protein. Its gene is located on chromosome 11. It belongs to the family of neurotrophins, proteins that promote the survival of neurons. Its existence is of great importance for brain development and increased brain plasticity throughout life. Brain-derived neurotrophic factor is one of the most important neurotrophins for cognitive function and is involved in processes such as long-term memory and learning. This would explain why it is found to a greater extent in the hippocampus and cerebral cortex. In addition, Mark Tuszynski, from the University of California, showed that BDNF, in animals, prevented neuronal death after brain injury and prevented cognitive dysfunction due to aging. This is due to its "curative" function on neurons. Main functions and mechanisms of actionAs mentioned above, the main function of brain-derived neurotrophic factor is to stimulate the growth of new neurons and brain connections. This is important for thinking and learning. But above all it has important implications for long-term memory. In addition to improving cognitive function, it also appears to protect the brain from neurodegenerative diseases, as BDNF levels have been shown to be decreased in patients with Alzheimer's disease. It is also capable of reducing the impact of stress on the brain and increasing its levels protects us from disorders such as depression and anxiety. In order to carry out its function, brain-derived neurotrophic factor requires cells to have receptors to bind to. One of these is the neurotrophic receptor tyrosine kinase B (Trkb), with which it forms the BDNF-Trkb pathway, important for the growth of neurons and the development of short-term memory. The other is LNGFR, which seems to be more involved in the avoidance of neuronal death. What diseases can reduce the level of brain-derived neurotrophic factor?First, aging, as a natural process, can cause brain-derived neurotrophic factor levels to decline. As we have seen, one of the structures where this protein was most present was the hippocampus, which is very important because of its relationship with memory. The reduction in the level of BDNF may be responsible for the reduction in size of this structure which, in turn, would be responsible for the normal cognitive deterioration associated with aging. Moreover, it has been shown that the expression of brain-derived neurotrophic factor is reduced by stress, which is a risk factor for the development of major depressive disorder. Stress-related disorders, including depression, correspond with a reduction in hippocampal size. This would explain the memory loss and other cognitive impairments observed in patients with depression. Reduced BDNF level has also been shown to be related to suicidal behaviors. Knowing the levels of brain-derived neurotrophic factor could help differentiate between patients with depression who are at risk of suicide and those who are not. In addition, a decrease in BDNF has been linked to other diseases such as obsessive-compulsive disorder, eating disorders, schizophrenia, Huntington's disease, post-traumatic stress disorder and Burnout. It is not yet entirely clear whether these reductions are a cause or a consequence of these disorders. However, this leaves the door open to possible forms of prevention and treatment for patients who do not respond to other treatments or even to treat diseases that currently have no cure, such as Alzheimer's disease. Can brain-derived neurotrophic factor levels be increased naturally? Indeed, they can. In fact, they can only be increased naturally. BDNF levels are affected by unhealthy lifestyles. Therefore, taking small actions that improve our habits and routines can help increase the level of this neurotrophin. One of the best ways to increase brain neurotrophic factor is physical exercise. The benefits are multiplied if it is done outdoors and under the sun. Spending time doing enjoyable activities such as listening to music or spending quality time with quality people may promote BDNF production. Diet is also important. The Mediterranean diet has been shown to improve BDNF levels, as long as we also manage to carry out calorie restriction. It is clear that we cannot always live on a low-calorie diet, but perhaps intermittent fasting could contribute something in this respect. In short... It seems clear that this "little one" is one of the most important proteins, as far as neuronal development is concerned, in our organism. Maintaining good levels of brain-derived neurotrophic factor does not cost anything, but it does a lot of good. If we all knew that it is in our power to improve BDNF levels and that doing so protects us from diseases and the harmful effects of the daily stress in which we are immersed, we would not hesitate to do so. Now there are no more excuses: it is as easy as it is important! You might be interested in... 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